Dynamic Networks in Biological Systems
The primary objectives of the laboratory are
(1) to discover the dynamic principles of how the biological networks
evolve and interact with the environment and
(2) to apply those
principles for pattern recognition, fault detection, and function recovery in
biological systems.
In particular, we study systems
in two categories:
(1) the neural development and adaptation, and,
(2) the gene expression and regulation.
Dr. Dawei W. Dong
Department of Biomedical Sciences
University of Pennsylvania
Philadelphia, PA 19104
Phone: (215) 898-9228
Cell : (561) 703-9039
E-Mail: dawei@dove.med.upenn.edu
WWW: http://dove.med.upenn.edu/~dawei
Selected Publications:
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Aggressive triple negative breast cancers have unique molecular signature on the basis of mitochondrial genetic and functional defects
by
Manti Guha, Satish Srinivasan, Pichai Raman, Yuefu Jiang, Brett A. Kaufman, Deanne Taylor, Dawei Dong, Rumela Chakrabarti, Martin Picard, Russ P. Carstens, Yuko Kijima, Mike Feldman, Narayan G Avadhani,
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, v1864(4A), p1060-1071,
doi:10.1016/j.bbadis.2018.01.002.
(Abstract
and
Online Paper)
-
Diverse functions of homologous actin isoforms are defined by their nucleotide, rather than their amino acid sequence
by
Pavan Vedula,
Satoshi Kurosaka,
Nicolae Adrian Leu,
Yuri I Wolf,
Svetlana A Shabalina,
Junling Wang,
Stephanie Sterling,
Dawei Dong,
Anna Kashina,
eLife,
6:e31661, doi:10.7554/eLife.31661.
(Abstract
and
Online Paper)
-
Arginyltransferase ATE1 is targeted to the neuronal growth cones and regulates neurite outgrowth during brain development
by
Junling Wang,
Iuliia Pavlyk,
Pavan Vedula,
Stephanie Sterling,
N. Adrian Leu,
Dawei W. Dong,
Anna Kashina,
Developmental Biology,
v430.1, p41-51, doi:10.1016/j.ydbio.2017.08.027.
(Abstract
and
Online Paper)
-
Protein arginylation targets alpha synuclein, facilitates normal brain health, and prevents neurodegeneration
by Junling Wang,
Xuemei Han,
Nicolae Adrian Leu,
Stephanie Sterling,
Satoshi Kurosaka,
Marie Fina,
Virginia M. Lee,
Dawei W. Dong,
John R. Yates III,
Anna Kashina,
Scientific Reports, v7, 11323, doi:10.1038/s41598-017-11713-z.
(Abstract
and
Online Paper)
-
Disruption of cytochrome c oxidase function induces Warburg effect and metabolic reprogramming
by Satish Srinivasan, Manti Guha, Dawei W. Dong, Kelly A. Whelan,
Gordon Ruthel, Yasuto Uchikado, Shoji Natsugoe, Hiroshi Nakagawa,
Narayan G. Avadhani,
Oncogene, v35, p1585-1595, doi:10.1038/onc.2015.227.
(Abstract
and
Online Paper)
-
Arginyltransferase ATE1 suppresses cell tumorigenic potential and inversely correlates with metastases in human cancers
by Reena Rai, Fangliang Zhang, Kristen Colavita, Nicolae Adrian Leu, Satoshi Kurosaka, Akhilesh Kumar, Michael D. Birnbaum, Balazs Gyorffy, Dawei W. Dong, Michael Shtutman, Anna Kashina,
Oncogene, v35, p4058-4068, doi:10.1038/onc.2015.473.
(Abstract
and
Online Paper)
-
Defects of cytochrome c oxidase expression induces a
metabolic shift to glycolysis and carcinogenesis
by Dawei W. Dong, Satish Srinivasan, Manti Guha,
Narayan G. Avadhani,
Genomics Data, v6, p99-107, doi:10.1016/j.gdata.2015.07.031.
(Abstract
and
Online Paper)
-
Association of G-quadruplex forming sequences with human mtDNA deletion breakpoints
by Dawei W. Dong, Filipe Pereira, Steven P. Barrett, Jill E. Kolesar, Kajia Cao, Joana Damas, Liliya A. Yatsunyk, F. Brad Johnson, and Brett A. Kaufman,
BMC Genomics, v15(1), 677, doi:10.1186/1471-2164-15-677.
(Abstract
and
Online Paper)
-
Maximizing causal information of natural scenes in motion
by Dawei W. Dong,
In: Dynamics of Visual Motion Processing (Ilg UJ and Masson GS eds),
p261-282, doi:10.1007/978-1-4419-0781-3_12,
(Abstract
and
Online Book)
-
Arginyltransferase regulates alpha cardiac actin function, myofibril formation and contractility during heart development
by
Reena Rai, Catherine C. L. Wong, Tao Xu, N. Adrian Leu, Dawei W. Dong, Caiying Guo, K. John McLaughlin, John R. Yates, III, and Anna Kashina,
Development, v135.23, p3881-3889, doi:10.1242/dev.022723.
(Abstract
and
Online Paper)