Dynamic Networks in Biological Systems

The primary objectives of the laboratory are (1) to discover the dynamic principles of how the biological networks evolve and interact with the environment and (2) to apply those principles for pattern recognition, fault detection, and function recovery in biological systems. In particular, we study systems in two categories: (1) the neural development and adaptation, and, (2) the gene expression and regulation.

Dr. Dawei W. Dong
Department of Biomedical Sciences
University of Pennsylvania
Philadelphia, PA 19104

Phone: (215) 898-9228
Cell : (561) 703-9039

Selected Publications:
  1. Aggressive triple negative breast cancers have unique molecular signature on the basis of mitochondrial genetic and functional defects by Manti Guha, Satish Srinivasan, Pichai Raman, Yuefu Jiang, Brett A. Kaufman, Deanne Taylor, Dawei Dong, Rumela Chakrabarti, Martin Picard, Russ P. Carstens, Yuko Kijima, Mike Feldman, Narayan G Avadhani, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, v1864(4A), p1060-1071, doi:10.1016/j.bbadis.2018.01.002. (Abstract and Online Paper)

  2. Diverse functions of homologous actin isoforms are defined by their nucleotide, rather than their amino acid sequence by Pavan Vedula, Satoshi Kurosaka, Nicolae Adrian Leu, Yuri I Wolf, Svetlana A Shabalina, Junling Wang, Stephanie Sterling, Dawei Dong, Anna Kashina, eLife, 6:e31661, doi:10.7554/eLife.31661. (Abstract and Online Paper)

  3. Arginyltransferase ATE1 is targeted to the neuronal growth cones and regulates neurite outgrowth during brain development by Junling Wang, Iuliia Pavlyk, Pavan Vedula, Stephanie Sterling, N. Adrian Leu, Dawei W. Dong, Anna Kashina, Developmental Biology, v430.1, p41-51, doi:10.1016/j.ydbio.2017.08.027. (Abstract and Online Paper)

  4. Protein arginylation targets alpha synuclein, facilitates normal brain health, and prevents neurodegeneration by Junling Wang, Xuemei Han, Nicolae Adrian Leu, Stephanie Sterling, Satoshi Kurosaka, Marie Fina, Virginia M. Lee, Dawei W. Dong, John R. Yates III, Anna Kashina, Scientific Reports, v7, 11323, doi:10.1038/s41598-017-11713-z. (Abstract and Online Paper)

  5. Disruption of cytochrome c oxidase function induces Warburg effect and metabolic reprogramming by Satish Srinivasan, Manti Guha, Dawei W. Dong, Kelly A. Whelan, Gordon Ruthel, Yasuto Uchikado, Shoji Natsugoe, Hiroshi Nakagawa, Narayan G. Avadhani, Oncogene, v35, p1585-1595, doi:10.1038/onc.2015.227. (Abstract and Online Paper)

  6. Arginyltransferase ATE1 suppresses cell tumorigenic potential and inversely correlates with metastases in human cancers by Reena Rai, Fangliang Zhang, Kristen Colavita, Nicolae Adrian Leu, Satoshi Kurosaka, Akhilesh Kumar, Michael D. Birnbaum, Balazs Gyorffy, Dawei W. Dong, Michael Shtutman, Anna Kashina, Oncogene, v35, p4058-4068, doi:10.1038/onc.2015.473. (Abstract and Online Paper)

  7. Defects of cytochrome c oxidase expression induces a metabolic shift to glycolysis and carcinogenesis by Dawei W. Dong, Satish Srinivasan, Manti Guha, Narayan G. Avadhani, Genomics Data, v6, p99-107, doi:10.1016/j.gdata.2015.07.031. (Abstract and Online Paper)

  8. Association of G-quadruplex forming sequences with human mtDNA deletion breakpoints by Dawei W. Dong, Filipe Pereira, Steven P. Barrett, Jill E. Kolesar, Kajia Cao, Joana Damas, Liliya A. Yatsunyk, F. Brad Johnson, and Brett A. Kaufman, BMC Genomics, v15(1), 677, doi:10.1186/1471-2164-15-677. (Abstract and Online Paper)

  9. Maximizing causal information of natural scenes in motion by Dawei W. Dong, In: Dynamics of Visual Motion Processing (Ilg UJ and Masson GS eds), p261-282, doi:10.1007/978-1-4419-0781-3_12, (Abstract and Online Book)

  10. Arginyltransferase regulates alpha cardiac actin function, myofibril formation and contractility during heart development by Reena Rai, Catherine C. L. Wong, Tao Xu, N. Adrian Leu, Dawei W. Dong, Caiying Guo, K. John McLaughlin, John R. Yates, III, and Anna Kashina, Development, v135.23, p3881-3889, doi:10.1242/dev.022723. (Abstract and Online Paper)